Draft genome sequence of Staphylococcus aureus ST672, an emerging disease clone from India

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Supriya Khedkar1, Sushma Prabhakara, Ramya Malarini Loganathan

  • 1Society for Innovation and Development, Indian Institute of Science Campus, Bangalore.

Journal of Bacteriology
|December 5, 2012
PubMed

Insights

We sequenced the methicillin-resistant Staphylococcus aureus (MRSA) ST672 genome, an emerging Indian clone. This strain, isolated from a septicemia patient, shows distinct genetic features compared to ST772, including its SCCmec element.

Area of Science:

  • Genomics
  • Microbiology
  • Infectious Diseases

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant global health threat.
  • Emerging MRSA clones, such as ST672 in India, require detailed genomic characterization to understand their spread and virulence.
  • Septicemia is a life-threatening condition often caused by bacterial infections.

Purpose of the Study:

  • To report the draft genome sequence of the MRSA ST672 strain.
  • To provide genomic insights into an emerging disease clone in India.
  • To conduct a preliminary comparison of key genetic elements with related strains.

Main Methods:

  • Whole-genome sequencing of MRSA ST672.
  • Bioinformatic analysis to identify open reading frames (ORFs).
  • Comparative analysis of staphylococcal cassette chromosome mec (SCCmec) and immune evasion clusters.

Main Results:

  • The draft genome sequence of MRSA ST672 was determined, measuring approximately 2.82 Mb with 2,485 ORFs.
  • The strain harbors a type V staphylococcal cassette chromosome mec (SCCmec) element.
  • Preliminary examination suggests differences in the SCCmec element and immune evasion cluster compared to MRSA ST772.

Conclusions:

  • The genomic data provides a foundation for understanding the genetic basis of MRSA ST672 emergence and pathogenicity.
  • The identified genetic differences may contribute to the distinct epidemiological profile of ST672.
  • Further research is warranted to fully elucidate the implications of these genetic variations.

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