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Updated: Aug 15, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
Non-steroidal anti-inflammatory drugs and gastric DNA synthesis
1Dept. of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Abstract:
In vitro incubation of endoscopic gastric antral biopsy specimens with tritiated thymidine, with confirmatory autoradiography, was used to assess gastric epithelial cell turnover in man and to investigate the effects of chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs). In the absence of NSAID administration, macroscopic erosions and ulceration in the antrum were associated with enhanced gastric epithelial cell proliferation. In patients taking NSAIDs erosions occurred without a compensatory increase in epithelial cell DNA synthesis. The failure to respond to injury by enhancing epithelial cell proliferation is likely to be an important factor in NSAID-induced gastric damage and supports a role for prostaglandins in enhancing mucosal repair by increasing epithelial cell generation.
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