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Published on: June 29, 2019
Effect of pancreatic enzymes in non-ulcer dyspepsia. A pilot study
P M Kleveland1, T Johannessen, P Kristensen
1Dept. of Medicine, Regional and University Hospital of Trondheim, Trondheim, Norway.
Abstract:
The symptomatic effect of pancreatic enzymes was examined in 37 patients with non-ulcer dyspepsia (NUD) recruited from general practice by means of a 24-day multicrossover model (MCOM) including six treatment periods and five regular interchanges between pancreatic enzymes and placebo. The evaluation was based on a comparison of the enzyme- and placebo-associated symptoms and on the number of times pancreatic enzymes were associated with less symptoms than the preceding or following placebo period in individual patients. No evidence of a short-term effect of pancreatic enzymes in NUD was found.
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