Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assessment of the Cardiovascular System III: Palpation

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A one-year exploratory randomized, controlled, multicentric pilot study evaluating the efficacy and tolerance of an anti-hair loss serum containing <i>Silybum marianum</i> extract, manganese PCA, and <i>Lespedeza capitata</i> extract following hair transplantation in men with androgenic alopecia.

Frontiers in medicine·2026

Same author

Effectiveness of Botulinum Toxin Type A for Trichodynia Associated with Hair Loss Disorders: A Retrospective Study.

Dermatology and therapy·2026

Same author

The Psychological Impact of Frontal Fibrosing Alopecia in Men: A Multicenter Cross-Sectional Study.

Skin appendage disorders·2026

Same author

Hair Loss in Patients on Glucagon-Like Peptide 1 Receptor Agonists: Understanding Risks and Managing Outcomes.

Dermatology and therapy·2026

Same author

Real-World Evidence That As-Needed Dosing with Bimekizumab in Patients with Psoriasis Is Safe and Effective over Time.

Journal of personalized medicine·2026

Same author

Gold-Induced Hypersensitivity Reaction After Fractional Radiofrequency Microneedling: A Case Report.

Contact dermatitis·2026

Search research articles

Related Experiment Video

Updated: May 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Skin rash associated with limb weakness.

Emiliano Grillo¹, Marta Urech, Angela Miguel-Morrondo

¹Department of Dermatology, Ramon Y Cajal University Hospital, Madrid, Spain. doctorgrillo85@hotmail.com

Australian Family Physician

|December 5, 2012

Summary

This case study highlights a rare presentation of a 77-year-old man with severe gastrointestinal bleeding and limb weakness. The unusual skin rash suggests a potential systemic condition requiring further investigation.

Related Experiment Videos

Last Updated: May 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Internal Medicine
Dermatology
Gastroenterology

Background:

A 77-year-old male patient with a history of unspecified comorbidities presented with acute symptoms.
The case underscores the importance of considering multi-system involvement in elderly patients.

Observation:

The patient presented with significant haematemesis (vomiting blood) and abdominal pain.
Progressive limb weakness was a notable neurological symptom.
A distinct skin rash was observed on the patient's chest and face.

Findings:

The constellation of haematemesis, abdominal pain, limb weakness, and rash suggests a complex underlying etiology.
Differential diagnoses may include vasculitis, autoimmune disorders, or paraneoplastic syndromes.

Implications:

This case emphasizes the need for a comprehensive diagnostic approach in patients with overlapping gastrointestinal, neurological, and dermatological symptoms.
Prompt and accurate diagnosis is crucial for effective management and improved patient outcomes in rare disease presentations.