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Long-term follow-up after leptospirosis.

O Shpilberg1, Y Shaked, M K Maier

  • 1Rusinow Department of Internal Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Southern Medical Journal
|April 1, 1990
PubMed
Summary

Long-term follow-up of human leptospirosis survivors reveals persistent ophthalmic and headache sequelae. While liver and kidney issues resolved, eye complications indicate ongoing morbidity years after the initial infection.

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Area of Science:

  • Infectious Diseases
  • Ophthalmology
  • Nephrology
  • Hepatology

Background:

  • Human leptospirosis is a significant global infectious disease, particularly prevalent in developing nations.
  • Survivors are often presumed to fully recover without long-term complications.
  • Limited research exists on the delayed sequelae following acute leptospirosis.

Purpose of the Study:

  • To investigate potential long-term sequelae in human leptospirosis survivors.
  • To reevaluate patients years after acute infection to identify persistent health issues.

Main Methods:

  • A cohort of eleven patients was reevaluated an average of 22 years post-acute leptospirosis.
  • Assessment focused on identifying delayed sequelae, including liver, renal, neurological, and ophthalmic conditions.

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Main Results:

  • Liver and renal disease associated with leptospirosis had resolved in all patients.
  • Persistent sequelae included chronic headaches and ophthalmic complications, particularly affecting the anterior chamber of the eyes.
  • The underlying cause of persistent headaches remains unknown.

Conclusions:

  • Human leptospirosis can lead to persistent ophthalmic sequelae and headaches long after the acute phase.
  • The eyes, specifically the anterior chambers, may represent a site of ongoing morbidity.
  • Further research is needed to understand the pathogenesis of persistent headache after leptospirosis.