Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics
Chang Won Kang1, Yongmao Sun, Juan R Del Valle
1Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States.
Organic Letters
|December 6, 2012
Abstract:
New conformationally extended dipeptide surrogates based on an imidazo[1,2-a]pyridine scaffold are described. Efficient synthesis and incorporation into host peptides affords structures with native side-chain functionality and hydrogen bonding elements on one face of the backbone. Structural analysis by NMR suggests that model peptidomimetics adopt a β-strand-like conformation in solution.


