Standard operating procedures for Peyronie's disease

Area of Science:

• Urology
• Andrology
• Sexual Medicine

Background:

• Peyronie's disease (PD) is a condition characterized by penile deformity.
• It is frequently linked to significant sexual dysfunction in affected males.
• The underlying causes of PD remain incompletely understood.

Purpose of the Study:

• To establish evidence-based recommendations and Standard Operating Procedures (SOPs) for diagnosing and treating Peyronie's disease.
• To synthesize current medical literature and expert opinions for clinical guidance.

Main Methods:

• Comprehensive review of existing medical literature.
• Integration of expert clinical opinion from the authors.
• Grading of evidence to formulate recommendations and SOPs.

Main Results:

• Peyronie's disease involves fibrotic scarring of the tunica albuginea, leading to penile curvature, shortening, and narrowing.
• Pain and diminished erectile quality are common early symptoms, impacting sexual function.
• A lack of effective, mechanistically targeted non-surgical therapies persists.

Conclusions:

• Effective management of Peyronie's disease requires accurate diagnosis and tailored treatment.
• Current treatment paradigms emphasize surgical correction for clear indications.
• Surgical options include tunica plication, plaque incision/excision with grafting, and penile prosthesis implantation.