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Updated: May 16, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Does diabetes have a protective effect on migraine?

Line Iden Berge¹, Trond Riise, Ole Bernt Fasmer

¹Department of Clinical Medicine, Section of Psychiatry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway. line.iden.berge@gmail.com

Epidemiology (Cambridge, Mass.)

|December 6, 2012

Summary

Migraine prevalence is lower in older adults with diabetes. Young individuals with diabetes may have increased migraine risk, but this risk decreases with age, suggesting a protective effect in older diabetic populations.

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Last Updated: May 16, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Area of Science:

Neurology
Endocrinology
Epidemiology

Background:

Diabetes mellitus is linked to increased risks of various chronic conditions.
Previous research shows conflicting associations between diabetes and migraine prevalence.
Age-dependent variations in migraine prevalence among diabetic patients necessitate further investigation.

Purpose of the Study:

To examine the prevalence of medically treated migraine in individuals with diabetes within the Norwegian population.
To investigate how diabetic drug treatment, sex, and age influence migraine prevalence.

Main Methods:

Cross-sectional analysis of prescription data from the Norwegian National Register of Prescriptions for 2006.
Inclusion of 124,649 individuals prescribed diabetes medication and 81,225 prescribed migraine medication.
Comparison of migraine prevalence between diabetic and non-diabetic populations.

Main Results:

Overall reduced prevalence of medically treated migraine in diabetic individuals (OR = 0.72).
Age-dependent pattern observed: increased prevalence in younger diabetics, decreasing with age.
Reduced migraine prevalence in diabetic patients aged 60-69 (OR = 0.4-0.6) compared to the general population, with no significant sex difference.

Conclusions:

A significantly lower prevalence of migraine exists in older patients with diabetes compared to the general population.
The findings suggest a potential protective role of diabetes against migraine, possibly linked to neuropathy.
Further research is warranted to elucidate the mechanisms behind the diabetes-migraine association.