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Non-celiac wheat sensitivity: separating the wheat from the chat!

David S Sanders, Imran Aziz

    The American Journal of Gastroenterology
    |December 6, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Patients with IBS-like symptoms may benefit from a gluten-free diet (GFD) even without celiac disease (CD). This highlights the emerging concept of non-celiac wheat sensitivity, offering new diagnostic and management approaches.

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    Area of Science:

    • Gastroenterology
    • Clinical Nutrition
    • Dietary Science

    Background:

    • Historically, undiagnosed celiac disease (CD) mimicked irritable bowel syndrome (IBS) symptoms, prompting testing recommendations.
    • Increased gluten-free diet (GFD) adoption suggests benefits beyond CD, hinting at non-celiac wheat sensitivity.
    • Confusion exists regarding the nomenclature and underlying mechanisms of non-celiac wheat sensitivity.

    Discussion:

    • The clinical concept of wheat sensitivity or intolerance is supported by emerging evidence.
    • A clinically applicable approach for wheat sensitivity is presented, potentially aiding international clinicians.
    • Differentiating gluten sensitivity from other wheat components like fructans remains a challenge.

    Key Insights:

    • Patients with IBS-type symptoms may experience relief with a GFD, irrespective of a CD diagnosis.
    • Non-celiac wheat sensitivity is an emerging area of research with significant clinical implications.
    • A practical management strategy for wheat sensitivity offers a new tool for gastroenterologists.

    Outlook:

    • Further research is needed to clarify the mechanisms and establish standardized diagnostic criteria for non-celiac wheat sensitivity.
    • International adoption of clinical approaches for wheat sensitivity could improve patient care.
    • Continued investigation into wheat components beyond gluten may reveal further insights into gastrointestinal sensitivities.