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Updated: May 16, 2026
03:38
Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
Published on: October 6, 2022
Targeting loop adenines in G-quadruplex by a selective oxirane
Filippo Doria1, Matteo Nadai2, Marco Folini3
1Dipartimento di Chimica, Università di Pavia, V.le Taramelli 10, 27100 Pavia (Italy).
Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 6, 2012
Abstract:
Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.
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