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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
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Bio-based biodegradable and biocompatible hyperbranched polyurethane: a scaffold for tissue engineering.

Beauty Das1, Pronobesh Chattopadhyay, Manabendra Mandal

  • 1Advanced Polymer & Nanomaterial Laboratory, Department of Chemical Sciences, Tezpur University, Tezpur 784028, India.

Macromolecular Bioscience
|December 6, 2012
PubMed
Summary
This summary is machine-generated.

Biodegradable hyperbranched polyurethanes (HBPU) were synthesized with and without sunflower oil monoglyceride. The HBPU with monoglyceride demonstrated superior biocompatibility and supported cell proliferation, indicating potential for tissue engineering scaffolds.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Hyperbranched polyurethanes (HBPU) are advanced polymers with unique properties.
  • Tailoring HBPU properties is crucial for specific applications, particularly in biomedical fields.
  • Investigating the impact of bio-based additives on HBPU performance is essential.

Purpose of the Study:

  • To synthesize and characterize hyperbranched polyurethanes (HBPU) using toluene diisocyanate (TDI), polycaprolactone (PCL) diol, butanediol, and pentaerythritol.
  • To evaluate the effect of incorporating sunflower oil monoglyceride (MG) on the properties and biocompatibility of HBPU.
  • To assess the suitability of HBPU as a scaffold material for tissue engineering.

Main Methods:

  • Synthesis of HBPU using TDI, PCL diol, butanediol, and pentaerythritol (1-5 wt%) as the B(4) reactant, with and without sunflower oil monoglyceride.
  • Characterization of biodegradation, physico-mechanical, and thermal properties.
  • In vitro biocompatibility assessment using MTT/hemolytic assays.
  • In vivo biocompatibility evaluation through subcutaneous implantation in Wistar rats, followed by cytokine/alkaline phosphatase (ALP) assays and histopathology.

Main Results:

  • Varying the percentage weight of the branching unit allowed tailoring of biodegradation, physico-mechanical, and thermal properties.
  • HBPU synthesized with sunflower oil monoglyceride (HBPU + MG) exhibited significantly better biocompatibility compared to HBPU without MG.
  • In vitro studies showed HBPU supports dermatocyte proliferation without toxic effects on major organs, and its in vitro degradation products are non-toxic.

Conclusions:

  • Bio-based HBPU, particularly with sunflower oil monoglyceride, demonstrates excellent biocompatibility and supports cell proliferation.
  • The tunable properties and non-toxic degradation products make HBPU a promising candidate for tissue engineering scaffold applications.
  • Further research into HBPU as a biomaterial for regenerative medicine is warranted.