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Aortic sclerosis is associated with mortality and major morbidity in patients undergoing coronary artery bypass

Aidan W Flynn1, Jonathan Afilalo, Arvind K Agnihotri

  • 1Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, Harvard University, 55 Fruit Street, Boston, MA 02114, USA.

Heart (British Cardiac Society)
|December 6, 2012
PubMed

Insights

Aortic sclerosis is common in patients undergoing coronary artery bypass grafting (CABG). Its presence independently predicts higher in-hospital and long-term mortality risks.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Vascular Medicine

Background:

  • Aortic sclerosis is a frequent finding in patients with coronary artery disease.
  • The prognostic implications of aortic sclerosis in patients undergoing coronary artery bypass grafting (CABG) require further investigation.

Purpose of the Study:

  • To assess the association between aortic sclerosis and in-hospital mortality and major morbidity.
  • To determine the impact of aortic sclerosis on long-term all-cause mortality in patients undergoing CABG.

Main Methods:

  • Retrospective analysis of preoperative echocardiograms from 627 patients undergoing isolated CABG.
  • Logistic regression and Cox proportional hazards models were used to evaluate outcomes.
  • In-hospital mortality, major morbidity, and long-term all-cause mortality were the primary endpoints.

Main Results:

  • 207 patients (33%) exhibited significant aortic sclerosis and had higher rates of cardiovascular risk factors.
  • Aortic sclerosis was significantly associated with increased in-hospital mortality or major morbidity (OR 1.90; 95% CI 1.15 to 3.11) after adjustment.
  • Aortic sclerosis was linked to a 2.52-fold increased risk of adjusted long-term all-cause mortality (mean follow-up 2.7 years).

Conclusions:

  • Aortic sclerosis is a prevalent condition in patients undergoing CABG.
  • The presence of aortic sclerosis independently predicts a higher risk of both in-hospital and long-term mortality in this patient cohort.
  • Echocardiographic assessment of aortic sclerosis may aid in risk stratification for patients undergoing CABG.
Abstract

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