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Related Experiment Video

Updated: May 16, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Neural stem cells in the diabetic brain.

Tomás P Bachor¹, Angela M Suburo

¹Medicina Celular y Molecular, Facultad de Ciencias Biomédicas, Universidad Austral, Buenos Aires, B1629AHJ Pilar, Argentina.

Stem Cells International

|December 6, 2012

Summary

This summary is machine-generated.

Experimental diabetes impacts adult brain stem cells and neurogenic niches, potentially causing cognitive deficits in patients. Early changes in these niches may contribute to the progression of diabetes.

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Area of Science:

Neuroscience
Endocrinology
Stem Cell Biology

Background:

Diabetes mellitus affects multiple organ systems, including the brain.
Adult neurogenic niches, responsible for generating new neurons, are crucial for brain function.
Dysfunction in these niches is implicated in cognitive impairments associated with diabetes.

Purpose of the Study:

To review the current understanding of adult neural stem cells.
To examine methods for studying neural stem cells in diabetic models.
To summarize the effects of experimental diabetes on neurogenic niches and associated cognitive disorders.

Main Methods:

Review of existing literature on experimental diabetes models.
Analysis of studies investigating adult neural stem cells and neurogenic niches.
Correlation of neurogenic niche alterations with behavioral and cognitive outcomes in diabetes.

Main Results:

Experimental diabetes significantly alters the structure and proliferation of adult neurogenic niches.
Hyperglycemia, even short-term, profoundly impacts neurogenic niche dynamics.
Alterations in diabetic neurogenic niches are linked to cognitive deficits observed in diabetic conditions.

Conclusions:

Early changes in adult neurogenic niches during diabetes may precede or exacerbate cognitive dysfunction.
Understanding these changes is critical for developing therapeutic strategies for diabetic cognitive disorders.
Neural stem cell research in diabetes provides insights into disease progression and potential interventions.