Related Experiment Video
Updated: May 16, 2026

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
Published on: December 4, 2018
Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
S Thanendrarajan1, Y Kim, I G H Schmidt-Wolf
1Department of Internal Medicine III (Hematology and Oncology), Center for Integrated Oncology (CIO), University of Bonn, Sigmund-Freud Stra β e 25, 53127 Bonn, Germany.
Abstract:
It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic leukemia. In this paper we provide an overview about the current state of knowledge regarding the Wnt/β-catenin signaling pathway in chronic leukemia with special focus on therapeutic options and strategies.
Related Concept Videos
Canonical Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathways
Non-Canonical Wnt Signaling Pathways
Catenins
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...