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[Fructosamine values in hyperthyroidism, hypothyroidism and gammopathy].
R N Weijers1, E H Slaats, H Kruijswijk
1Department of Clinical Chemistry, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Wiener Klinische Wochenschrift. Supplementum
|January 1, 1990
Summary
Fructosamine is not a reliable indicator of glucose control in hyperthyroid patients, as values are significantly lower. Correction factors with protein or albumin are not recommended.
Area of Science:
- Endocrinology
- Clinical Chemistry
Context:
- Thyroid dysfunction, specifically hyperthyroidism, can alter serum protein concentrations.
- Fructosamine is a marker used to assess long-term glycemic control.
Purpose:
- To evaluate the reliability of fructosamine as a glycemic marker in hypo- and hyperthyroid patients compared to non-diabetic controls.
- To investigate the relationship between fructosamine, albumin, and total protein levels in thyroid dysfunction.
Summary:
- Hyperthyroid patients exhibited significantly lower fructosamine levels compared to a non-diabetic reference group.
- Serum albumin and total protein were also lower in hyperthyroid patients versus hypothyroid patients.
- No clear correlation was found between fructosamine and protein/albumin levels, advising against correction factors.
Impact:
- Fructosamine testing is unreliable for assessing glycemic control in patients with thyrotoxicosis.
- Monoclonal IgG gammopathy does not interfere with fructosamine assay results.