Normative growth data for the external diameters of the external and internal iliac arteries in human fetuses--an anatomical, digital and statistical study
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1Department of Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Bydgoszcz, Poland. kizanat@cm.umk.pl
Insights
Normal growth of fetal external and internal iliac artery diameters follows quadratic functions, independent of sex. The internal iliac artery diameter is larger than the external iliac artery, with a trend towards larger right-sided vessels.
Area of Science:
- Anatomy
- Developmental Biology
- Vascular Biology
Background:
- Normative data for aorto-iliac segment diameters are crucial for diagnosing and monitoring prenatal arterial variations and pathologies.
- Understanding normal arterial development aids in identifying congenital anomalies and planning interventions.
Purpose of the Study:
- To establish age-specific reference intervals for external iliac artery (EIA) and internal iliac artery (IIA) diameters.
- To generate normal growth curves for these arteries during fetal development.
Main Methods:
- Anatomical dissection and digital-image analysis were employed.
- The study analyzed 124 human fetuses aged 15–34 weeks.
- External diameters of the EIA and IIA were measured.
Main Results:
- EIA external diameters increased from 0.29–0.31 mm to 1.37–1.41 mm, following quadratic growth curves (R² = 0.82–0.86).
- IIA external diameters ranged from 0.44 mm to 1.83–2.04 mm, also modeled by quadratic functions (R² = 0.74–0.76).
- IIA diameters were statistically larger than EIA diameters; a trend towards larger right-sided vessels was observed, though sex differences were not significant.
Conclusions:
- Fetal EIA and IIA external diameters are independent of sex.
- IIA external diameter is approximately 1.5 times larger than EIA external diameter.
- Normal growth patterns for these arterial segments are best described by quadratic functions.
Background:
Normative data on the diameters of the aorto-iliac segment are extremely useful in the diagnosis and monitoring of prenatal arterial variants and pathologies.
Objectives:
The present study describes age-specific reference intervals and normal growth curves for the external diameters of the external and internal iliac arteries.
Material And Methods:
Using anatomical dissection and digital-image analysis, the normal growth of the external diameters of the external and internal iliac arteries was studied in 124 spontaneously aborted human fetuses, aged 15-34 weeks.
Results:
Neither sex differences nor laterality differences were found. The external diameters of the external iliac arteries increased from 0.31 +/- 0.06 to 1.41 +/- 0.31 mm on the right, and from 0.29 +/- 0.04 to 1.37 +/- 0.24 mm on the left, and generated the following growth curves of best fit: y = 0.665 - 0.056 x Age + 0.002 x Age2 +/- 0.143 (R2 = 0.82) and y = 0.612 - 0.052 x Age + 0.002 x Age2 +/- 0.118 (R2 = 0.86), respectively. The external diameters of the internal iliac arteries were found to be statistically larger than those of the external iliac arteries (p = 0.0000). The external diameters of the internal iliac arteries ranged from 0.44 +/- 0.07 to 2.04 +/- 0.43 mm on the right, and from 0.44 +/- 0.06 to 1.83 +/- 0.43 mm on the left, and modeled the following quadratic functions: y = 1.524 - 0.127 x Age + 0.004 x Age2 +/- 0.242 (R2 = 0.74), and y = 1.391 - 0.117 x Age + 0.004 x Age2 +/- 0.220 (R2 = 0.76), respectively. The right external iliac arteries (in 71% of the cases) and the right internal iliac arteries (in 65.3% of cases) were larger in external diameter.
Conclusions:
The values of the external diameters of the external and internal iliac arteries are independent of sex. A strong trend towards higher values for the right external and internal iliac arteries is noted. The external diameter of the internal iliac artery is nearly 1.5 times greater than that of the external iliac artery. Surprisingly, normal growth of the external diameters of the external and internal iliac arteries follows quadratic functions.
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