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The occurrence of calicivirus in infants with acute gastroenteritis

H Suzuki, T Konno, T Kutsuzawa

    Journal of Medical Virology
    |January 1, 1979
    PubMed

    Insights

    Calicivirus was identified in hospitalized infants and young children with acute gastroenteritis. This study suggests calicivirus may be a significant cause of this common childhood illness.

    Area of Science:

    • Pediatric Infectious Diseases
    • Virology
    • Gastroenterology

    Background:

    • Acute gastroenteritis is a common illness in infants and young children.
    • Viral pathogens are frequently implicated in acute gastroenteritis.
    • The role of specific viruses, such as calicivirus, requires further investigation.

    Purpose of the Study:

    • To investigate the prevalence of calicivirus in hospitalized infants and young children with acute gastroenteritis.
    • To characterize the morphology and physical properties of the detected calicivirus.
    • To assess the serologic response to calicivirus infection.

    Main Methods:

    • A survey of 647 hospitalized infants and young children with acute gastroenteritis.
    • Detection of calicivirus in stool samples using electron microscopy.
    • Morphological characterization and buoyant density determination of the virus.
    • Serologic testing using immune electron microscopy (IEM) on paired sera.

    Main Results:

    • Calicivirus was detected in 8 (1.2%) of the 647 patients.
    • The virus measured approximately 30 nm in diameter and exhibited a "star of David" morphology.
    • Buoyant density in cesium chloride was 1.38-1.40 gm/ml.
    • Serologic response was confirmed in patients shedding the virus.

    Conclusions:

    • Calicivirus was identified as a potential cause of acute gastroenteritis in infants and young children.
    • The findings highlight the importance of considering calicivirus in pediatric gastroenteritis outbreaks.
    • Further research is warranted to fully understand the epidemiology and clinical impact of calicivirus in this age group.

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