Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...
Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either weak...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Facilitated Transport01:19

Facilitated Transport

The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a membrane via...
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversal of tracer advection and Hall drift in an interacting chiral fluid.

Physical review. E·2026
Same author

Reliability of a nonlinear fluctuation-dissipation relation as a test of Markovianity.

Physical review. E·2026
Same author

Hitting the blinking target under stochastic resetting.

Chaos (Woodbury, N.Y.)·2026
Same author

Universalities in a constrained motion of a particle with memory friction: A bead of a Rouse chain on a periodic wire.

Physical review. E·2026
Same author

Anomalous statistics in the Langevin equation with fluctuating diffusivity: from Brownian yet non-Gaussian diffusion to anomalous diffusion and ergodicity breaking.

Reports on progress in physics. Physical Society (Great Britain)·2026
Same author

Anomalous diffusion and fluctuations in complex systems and networks.

Chaos (Woodbury, N.Y.)·2026
Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
See all related articles

Related Experiment Video

Updated: May 16, 2026

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Bulk-mediated diffusion on a planar surface: full solution.

Aleksei V Chechkin1, Irwin M Zaid, Michael A Lomholt

  • 1Institute for Theoretical Physics NSC KIPT, Akademicheskaya st. 1, 61108 Kharkov, Ukraine.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Particles exhibit superdiffusive surface motion when they intermittently leave and return to a surface. Our random-walk model reveals Cauchy-type behavior with specific cutoffs, explaining this effective surface diffusion.

More Related Videos

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

Related Experiment Videos

Last Updated: May 16, 2026

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

Area of Science:

  • Statistical Physics
  • Surface Science
  • Condensed Matter Physics

Background:

  • Understanding particle dynamics on surfaces is crucial for various scientific fields.
  • Intermittent surface unbinding and bulk excursions lead to complex effective surface motion.
  • Existing models may not fully capture the coupling between surface and bulk diffusion.

Purpose of the Study:

  • To derive diffusion equations for surface and bulk motion, including their coupling.
  • To analytically determine the propagator for the effective surface motion.
  • To investigate the superdiffusive behavior and long-time dynamics of surface-confined particles.

Main Methods:

  • Utilized a random-walk approach to model particle behavior.
  • Derived exact dynamic equations for coupled surface and bulk diffusion.
  • Analytically obtained the propagator describing the effective surface motion.

Main Results:

  • Identified a superdiffusive, Cauchy-type behavior for the effective surface motion.
  • Derived exact cutoffs that limit the Cauchy form of the surface motion.
  • Analyzed the long-time dynamics of the particle's surface movement.

Conclusions:

  • The random-walk model accurately describes coupled surface-bulk diffusion.
  • Superdiffusion with specific cutoffs characterizes the effective surface particle motion.
  • The findings provide a theoretical framework for understanding intermittent surface dynamics.