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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Related Experiment Video

Updated: May 16, 2026

Discovering Protein Interactions and Characterizing Protein Function Using HaloTag Technology
11:16

Discovering Protein Interactions and Characterizing Protein Function Using HaloTag Technology

Published on: July 12, 2014

Emerging techniques in proteomics for probing nano-bio interactions.

Zon W Lai1, Yan Yan, Frank Caruso

  • 1Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.

ACS Nano
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Nanoengineered particles offer targeted therapy by forming a protein corona that influences cellular responses. Proteomics reveals how these nano-bio interactions guide particle design for better drug delivery and lesion-specific treatment.

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Last Updated: May 16, 2026

Discovering Protein Interactions and Characterizing Protein Function Using HaloTag Technology
11:16

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Published on: July 12, 2014

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Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Proteomics

Background:

  • Nanoengineered particles are crucial for drug formulation and targeted lesion therapy.
  • Understanding nano-bio interactions is key to advancing nanoparticle development.
  • The protein corona, formed by biological fluids on particle surfaces, significantly impacts nanoparticle behavior.

Purpose of the Study:

  • To review recent advancements in using proteomics to study nano-bio interactions.
  • To highlight the role of the protein corona in nanoparticle function.
  • To discuss how insights into nano-bio interactions can improve nanoparticle design for therapy.

Main Methods:

  • Mass-spectrometry-based proteomics techniques.
  • Integration with other emerging technologies.
  • Analysis of protein corona formation and its effects.

Main Results:

  • Proteomics provides novel insights into protein corona composition.
  • Understanding protein corona modulation is essential for predicting cellular responses.
  • Nano-bio interactions directly influence particle efficacy in biological systems.

Conclusions:

  • Proteomics is a powerful tool for elucidating nano-bio interactions.
  • Knowledge of the protein corona is critical for designing effective nano-therapeutics.
  • Further research in this area will enhance lesion-specific drug delivery and treatment outcomes.