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Updated: May 16, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Substitution effect on the one- and two-photon sensitivity of DMAQ "caging" groups
Morgane Petit1, Christine Tran, Thomas Roger
1Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, France.
Abstract:
The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.
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