Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gene expression profiles of carotid plaques differ between patients with amaurosis fugax and those with cerebral transient ischemic attack or stroke.

Cardiovascular research·2026

Same author

Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype.

Circulation research·2026

Same author

Genetically determined ancestry associates with morphological and molecular carotid plaque features.

Atherosclerosis·2026

Same author

Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy.

European heart journal·2026

Same author

Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β.

Circulation research·2026

Same author

Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease.

EBioMedicine·2025

Search research articles

Related Experiment Video

Updated: May 16, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Temporal changes of soluble ST2 after cardiovascular interventions.

Sanne Willems¹, Jan-Willem Sels, Suzanne Flier

¹Department of Experimental Cardiology, University Medical Centre Utrecht, 3584 CX, Utrecht, The Netherlands. s.willems-3@umcutrecht.nl

European Journal of Clinical Investigation

|December 11, 2012

Summary

Soluble ST2 (sST2) levels significantly increase after cardiovascular interventions like CABG, PCI, and peripheral surgery. This rise must be considered when using sST2 as a biomarker for cardiovascular disease prediction.

Related Experiment Videos

Last Updated: May 16, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Area of Science:

Cardiology
Biomarker Discovery
Clinical Chemistry

Background:

Soluble ST2 (sST2) is a potential biomarker for heart failure and mortality in cardiovascular diseases.
The impact of clinical factors and interventions on sST2 variability is not well understood.

Purpose of the Study:

To investigate the effect of cardiovascular interventions and clinical characteristics on plasma sST2 levels.
To explore the variability of sST2 in patients undergoing major cardiovascular procedures.

Main Methods:

Assessed sST2 levels in plasma from patients undergoing coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or peripheral vascular surgery.
Correlated sST2 levels with age and other clinical/biomarker data.

Main Results:

Age was the only significant correlating risk factor for sST2 levels.
sST2 levels markedly increased 1 and 24 hours post-CABG and 24 hours post-peripheral interventions.
sST2 levels remained significantly elevated 2 months post-PCI compared to baseline.
No association was found between sST2 and inflammatory or cardiac-specific markers.

Conclusions:

Cardiovascular interventions significantly elevate sST2 levels.
Recent cardiovascular interventions are a key determinant of sST2 levels.
Clinical interpretation of sST2 as a predictive biomarker requires accounting for recent interventions.