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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Related Experiment Video

Updated: May 16, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Transfusion practices in postpartum hemorrhage: a population-based study.

Marie-Pierre Bonnet1, Catherine Deneux-Tharaux, Corinne Dupont

  • 1INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Port Royal Maternity Unit, Cochin Teaching Hospital, Paris, France. marie-pierre.bonnet@inserm.fr

Acta Obstetricia Et Gynecologica Scandinavica
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Red blood cell (RBC) transfusions for postpartum hemorrhage (PPH) were underutilized in women with low hemoglobin, despite guidelines. Operative vaginal delivery led to greater blood loss and more transfusions compared to spontaneous delivery.

Related Experiment Videos

Last Updated: May 16, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Clinical Transfusion Medicine

Background:

  • Postpartum hemorrhage (PPH) remains a significant cause of maternal morbidity and mortality worldwide.
  • Current transfusion guidelines for PPH aim to optimize patient outcomes by ensuring timely and appropriate red blood cell (RBC) administration.
  • Variations in transfusion practices may exist based on clinical context, mode of delivery, and patient characteristics.

Purpose of the Study:

  • To investigate transfusion practices and the incidence of postpartum anemia in women experiencing PPH.
  • To analyze transfusion patterns in relation to the clinical context, including mode of delivery and cause of PPH.
  • To compare actual transfusion practices against established guidelines for RBC transfusion in PPH.

Main Methods:

  • A population-based cohort study was conducted across 106 French maternity units.
  • Data from 146,781 deliveries between December 2004 and November 2006 were analyzed.
  • The study focused on 9,365 women diagnosed with PPH, examining RBC transfusion rates and postpartum anemia.

Main Results:

  • Only 7.5% of women with PPH received RBC transfusions, with half of those having hemoglobin <7.0 g/dL not receiving transfusions, contrary to guidelines.
  • Operative vaginal delivery was associated with greater hemoglobin drop, increased use of fresh-frozen plasma (FFP) and pro-hemostatic agents, and higher rates of massive RBC transfusion compared to spontaneous vaginal delivery.
  • Women who underwent operative vaginal delivery also showed a higher likelihood of requiring conservative surgery.

Conclusions:

  • A significant proportion of women with PPH and critically low hemoglobin levels did not receive RBC transfusions, indicating a gap between guidelines and clinical practice.
  • Operative vaginal delivery is a significant risk factor for increased blood loss and greater transfusion requirements in the context of PPH.
  • These findings highlight the need for adherence to transfusion guidelines and careful management of PPH, particularly in cases of operative vaginal delivery.