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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Fatigue, emotional functioning, and executive dysfunction in pediatric multiple sclerosis.

Alice Ann Holland1, Donna Graves, Benjamin M Greenberg

  • 1a Children's Medical Center Dallas , Dallas , Texas , USA.

Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Pediatric multiple sclerosis (MS) is linked to fatigue, emotional issues, and executive dysfunction. These cognitive problems correlate with fatigue and emotional difficulties, not disease duration or age.

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Area of Science:

  • Pediatric neurology
  • Neuropsychology
  • Child psychology

Background:

  • Multiple sclerosis (MS) in adults is associated with fatigue, depression, anxiety, and executive dysfunction.
  • Research suggests these issues may also affect pediatric MS patients, but their interrelationships are not well understood.

Purpose of the Study:

  • To investigate the associations between executive functioning and fatigue, emotional functioning, age of onset, and disease duration in pediatric MS patients.

Main Methods:

  • Evaluated 26 pediatric MS/CIS patients (ages 7-18) using neuropsychological tests (Verbal Fluency, Digit Span, Trail-Making Test).
  • Collected parent/patient reports on behavior, emotion, quality of life, and fatigue.
  • Used Pearson's correlation coefficients to analyze relationships between variables.

Main Results:

  • Parent-reported anxiety, depression, fatigue, and executive dysfunction varied widely.
  • Patients showed below-average performance on the Trail-Making Test, with average scores on Verbal Fluency and Digit Span.
  • Fatigue and emotional functioning indices significantly correlated with executive functioning measures, but not age of onset or disease duration.

Conclusions:

  • Pediatric MS is associated with fatigue, emotional difficulties, and executive dysfunction.
  • Executive dysfunction in pediatric MS is linked to fatigue and emotional challenges.
  • Age of onset and disease duration were not significant predictors of executive functioning in this cohort.