Related Experiment Video
Updated: May 16, 2026
09:31
Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Published on: September 17, 2021
Local oxidative stress in interdigital tinea pedis
Perihan Ozturk1, Ozer Arican, Ergul B Kurutas
1Department of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. drperihanozturk@hotmail.com
The Journal of Dermatology
|December 11, 2012
Summary
This study shows that skin affected by tinea pedis (fungal foot infection) has higher levels of oxidative stress biomarkers. The skin
Area of Science:
- Dermatology
- Biochemistry
- Mycology
Background:
- Oxidative stress is linked to various skin diseases.
- Tinea pedis is a common fungal infection of the feet.
- The role of oxidative stress in tinea pedis has not been previously investigated.
Purpose of the Study:
- To investigate the oxidative stress status in skin affected by interdigital tinea pedis.
- To compare oxidative stress biomarkers between lesional and non-lesional skin in patients with tinea pedis.
Main Methods:
- Spectrophotometric measurement of oxidative stress biomarkers: superoxide dismutase (SOD), catalase, and malondialdehyde (MDA).
- Samples collected via skin scraping from 31 patients with unilateral interdigital tinea pedis.
- Comparison of biomarker levels between lesional and non-lesional skin areas.
Main Results:
- Significantly higher activities of SOD and catalase were observed in lesional skin compared to non-lesional skin (P < 0.001).
- Significantly higher levels of MDA were found in lesional skin compared to non-lesional skin (P < 0.001).
- No significant differences in biomarker levels were found based on sex or fungal subtypes.
Conclusions:
- Lesional skin in tinea pedis exhibits elevated oxidative stress biomarkers.
- Increased antioxidant defense in affected skin may be a compensatory response to fungal infection.
- These findings suggest oxidative stress plays a role in the pathogenesis of tinea pedis.
Related Concept Videos
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:00Cellular Injury I: Introduction
Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...