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Local oxidative stress in interdigital tinea pedis

Perihan Ozturk1, Ozer Arican, Ergul B Kurutas

  • 1Department of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. drperihanozturk@hotmail.com

The Journal of Dermatology
|December 11, 2012
PubMed

Insights

This study shows that skin affected by tinea pedis (fungal foot infection) has higher levels of oxidative stress biomarkers. The skin

Area of Science:

  • Dermatology
  • Biochemistry
  • Mycology

Background:

  • Oxidative stress is linked to various skin diseases.
  • Tinea pedis is a common fungal infection of the feet.
  • The role of oxidative stress in tinea pedis has not been previously investigated.

Purpose of the Study:

  • To investigate the oxidative stress status in skin affected by interdigital tinea pedis.
  • To compare oxidative stress biomarkers between lesional and non-lesional skin in patients with tinea pedis.

Main Methods:

  • Spectrophotometric measurement of oxidative stress biomarkers: superoxide dismutase (SOD), catalase, and malondialdehyde (MDA).
  • Samples collected via skin scraping from 31 patients with unilateral interdigital tinea pedis.
  • Comparison of biomarker levels between lesional and non-lesional skin areas.

Main Results:

  • Significantly higher activities of SOD and catalase were observed in lesional skin compared to non-lesional skin (P < 0.001).
  • Significantly higher levels of MDA were found in lesional skin compared to non-lesional skin (P < 0.001).
  • No significant differences in biomarker levels were found based on sex or fungal subtypes.

Conclusions:

  • Lesional skin in tinea pedis exhibits elevated oxidative stress biomarkers.
  • Increased antioxidant defense in affected skin may be a compensatory response to fungal infection.
  • These findings suggest oxidative stress plays a role in the pathogenesis of tinea pedis.

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