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Treatment update of sensitized pediatric kidney transplant recipients: a review

Hasan Otukesh1, Rozita Hoseini, Nahid Rahimzadeh

  • 1Pediatric Transplantation Dialysis Research Center, Tehran University of Medical Science, Tehran, Iran.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|December 11, 2012
PubMed

Sensitization of recipients is an increasing problem in children. Some case series in children exist comparing the diverse desensitizing protocols. These protocols include intravenous immunoglobulin, cytomegalovirus immune globulin, plasmapheresis, and some adjunctive therapies such as rituximab. Desensitizing protocols have advantages and disadvantages. Clinical trials are required to determine suitable protocols for sensitized pediatric recipients. We performed a systematic review of these protocols in children. A massive search was done in PubMed, Embase, and the Cochrane library system. The results of these studies are compared.

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