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Diagnostic criteria and laboratory tests for disseminated intravascular coagulation

Hideo Wada1, Takeshi Matsumoto, Tuyoshi Hatada

  • 1Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan. wadahide@clin.medic.mie-u.ac.jp.

Expert Review of Hematology
|December 11, 2012
PubMed

Insights

Current disseminated intravascular coagulation (DIC) diagnostic criteria show no significant differences in predicting outcomes. Future third-generation criteria will incorporate hemostatic molecular markers for improved accuracy.

Area of Science:

  • Hematology
  • Clinical Diagnostics

Background:

  • Disseminated intravascular coagulation (DIC) diagnosis relies on established criteria.
  • Existing criteria include first-generation (global coagulation tests) and second-generation (global tests plus test changes).

Purpose of the Study:

  • To review and compare existing DIC diagnostic criteria.
  • To highlight the need for future advancements in DIC diagnostics.

Main Methods:

  • Analysis of established diagnostic criteria from Japanese Ministry of Health, Labor and Welfare, International Society on Thrombosis and Hemostasis (ISTH), and Japanese Association for Acute Medicine.
  • Comparison of first-generation, second-generation, and proposed third-generation DIC diagnostic approaches.

Main Results:

  • No significant differences were found among the three current diagnostic criteria in predicting poor patient outcomes.
  • First-generation criteria utilize global coagulation tests, while second-generation criteria incorporate changes in these tests.

Conclusions:

  • Third-generation DIC diagnostic criteria, incorporating hemostatic molecular markers, are anticipated.
  • Standardization and determination of adequate cutoff values for laboratory tests are crucial for future criteria development.

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