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Related Experiment Video

Updated: May 16, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

Baroreflex sensitivity in asymptomatic coronary atherosclerosis.

Sakari Simula¹, Tomi Laitinen, Esko Vanninen

¹Department of Neurology, Mikkeli Central Hospital, Mikkeli, Finland.

Clinical Physiology and Functional Imaging

|December 11, 2012

Summary

Reduced baroreflex sensitivity (BRS) is linked to early signs of coronary artery disease (CAD) in asymptomatic individuals. This finding suggests that impaired BRS may indicate underlying subclinical atherosclerosis in those at high risk for heart disease.

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Area of Science:

Cardiology
Autonomic Nervous System Function
Vascular Physiology

Background:

Baroreflex sensitivity (BRS) is a key indicator of cardiac parasympathetic regulation.
Impaired BRS is observed in established coronary artery disease (CAD) and post-myocardial infarction, with prognostic value.
The presence of impaired BRS in asymptomatic individuals with subclinical coronary atherosclerosis remains unclear.

Purpose of the Study:

To investigate the association between baroreflex sensitivity (BRS) and subclinical coronary atherosclerosis in asymptomatic individuals at high familial risk for CAD.
To determine if impaired BRS is present in individuals with early, undetected coronary atherosclerosis.

Main Methods:

Evaluated 31 asymptomatic subjects with high familial risk for CAD.
Assessed BRS using the phenylephrine technique.
Quantified coronary atherosclerosis severity using quantitative coronary angiography (QCA), calculating percentage of diameter stenosis (PDS).
Ruled out myocardial perfusion defects using single photon emission tomography (SPECT).

Main Results:

BRS showed an inverse correlation with the percentage of diameter stenosis (PDS) in proximal coronary artery segments (r = -0.315, P<0.05) and the most severe single coronary artery stenosis (r = -0.374, P<0.05).
Subjects with severely blunted BRS (≤ 3 ms mmHg(-1)) exhibited significantly more severe PDS in proximal coronary segments (24 ± 7%) compared to those with higher BRS (> 3 ms mmHg(-1), 13 ± 11%, P<0.05).

Conclusions:

Impaired baroreflex sensitivity (BRS) is associated with the severity of subclinical coronary atherosclerosis in asymptomatic individuals with familial risk for CAD.
Severely blunted BRS in asymptomatic subjects may indicate the presence of advanced coronary atherosclerosis, suggesting BRS as a potential early marker.