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Related Experiment Video

Updated: May 16, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

VEGFA and tumour angiogenesis.

L Claesson-Welsh¹, M Welsh

¹Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. Lena.Welsh@igp.uu.se

Journal of Internal Medicine

|December 11, 2012

Summary

Vascular Endothelial Growth Factor A (VEGFA) signaling drives angiogenesis and vascular permeability, crucial for tumor growth. Understanding these complex pathways is key to overcoming resistance to anti-angiogenic therapies.

Area of Science:

Molecular Biology
Cell Biology
Oncology

Background:

Vascular Endothelial Growth Factor A (VEGFA) is a key regulator of angiogenesis and vascular permeability.
VEGFA exerts its effects through its receptor VEGFR2, initiating complex intracellular signaling cascades.
Dysfunctional tumor vasculature, driven by VEGFA, is a hallmark of many cancers.

Purpose of the Study:

To review the current understanding of signal transduction downstream of VEGFA and VEGFR2.
To elucidate the relationship between VEGFA signaling pathways and angiogenesis/vascular permeability.
To explore the implications for tumor angiogenesis and resistance to anti-angiogenic therapies.

Main Methods:

Literature review of signal transduction pathways.

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Last Updated: May 16, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

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Published on: March 15, 2016

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Published on: March 20, 2026

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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Analysis of effector molecules involved in VEGFA responses.

Examination of the role of VEGFA in tumor angiogenesis and therapeutic resistance.

Main Results:

VEGFA signaling involves multiple effectors including ERKs, PI3K/Akt, FAK, Rho GTPases, endothelial NO, and p38 MAPK.
These pathways regulate both angiogenesis and vascular permeability, with significant overlap.
Tumor angiogenesis driven by VEGFA often results in a dysfunctional vasculature that promotes tumor expansion.

Conclusions:

The complex and redundant nature of VEGFA signaling contributes to tumor angiogenesis and vascular dysfunction.
Understanding these intricate pathways is crucial for developing effective anti-angiogenic cancer therapies.
The complexity of VEGFA signaling may underlie common resistance mechanisms to therapies targeting this pathway.