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A Multi-detection Assay for Malaria Transmitting Mosquitoes
Published on: February 28, 2015
Plasmodium vivax malaria in Mali: a study from three different regions
Maria Bernabeu1, Gloria P Gomez-Perez, Sibiri Sissoko
1Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain. .
Malaria Journal
|December 11, 2012
Summary
Plasmodium vivax malaria is now circulating in sub-Saharan Africa, challenging previous assumptions. This study confirms P. vivax infections in Northern Mali, necessitating updated malaria control strategies.
Area of Science:
- Malariology
- Infectious Diseases
- Molecular Diagnostics
Background:
- Plasmodium vivax malaria was historically considered absent in West and Central Africa due to Duffy blood group absence.
- Recent evidence suggests P. vivax circulation in sub-Saharan Africa, prompting further investigation.
Purpose of the Study:
- To investigate the presence and confirm Plasmodium vivax infections in Northern Mali.
- To assess the diagnostic implications for malaria control in the region.
Main Methods:
- Microscopic examination of Giemsa/Field-stained blood smears from febrile patients in five Malian cities.
- Confirmatory diagnosis using nested-PCR and DNA sequence analysis of selected samples.
Main Results:
- Plasmodium vivax infections were detected in approximately 30% of the examined cases.
- Nested-PCR and DNA sequencing unequivocally confirmed the presence of P. vivax.
Conclusions:
- The findings confirm P. vivax circulation in Northern Mali, contrary to historical assumptions.
- Malaria diagnostics and control strategies in sub-Saharan Africa must account for P. vivax presence.
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