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Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy
Hong-Zin Lin1, Cheng-Yoong Pang, Shee-Ping Chen
1Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Abstract:
In this report, we describe a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy. The family carried a mitochondrial DNA mutation (mtDNA m.14484T>C) associated with spontaneous visual improvement. A 15-year-old boy from this family was diagnosed with Leber's hereditary optic neuropathy 6 months after losing his vision. His vision recovered after 8 months of supportive treatment. His mother, older brother, and two sisters also had the same mutation and had previously experienced vision loss. In this family, there was no male predominance.
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