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Related Experiment Video

Updated: May 16, 2026

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain
09:42

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Optogenetic inactivation modifies monkey visuomotor behavior.

James Cavanaugh1, Ilya E Monosov, Kerry McAlonan

  • 1Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20982-4435, USA. jrc@lsr.nei.nih.gov

Neuron
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

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Optogenetic inactivation of superior colliculus neurons in monkeys caused deficits in saccadic eye movements. This study evaluates optogenetic techniques for studying neuronal bases of behavior in non-human primates.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Primate Research

Background:

  • Understanding neuronal activity's role in behavior requires perturbing it.
  • Optogenetics offers reversible neuronal activity alteration, unlike chemical methods.
  • Optogenetics has succeeded in rodents but faces challenges in monkeys.

Purpose of the Study:

  • To demonstrate optogenetic inactivation of superior colliculus neurons in awake monkeys.
  • To assess the impact on saccadic eye movements.
  • To evaluate principles for optogenetic technique application in primate behavioral neuroscience.

Main Methods:

  • Optogenetic inactivation of superior colliculus neurons in awake monkeys.
  • Analysis of saccadic eye movement metrics.

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Last Updated: May 16, 2026

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Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates

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  • Evaluation of experimental design parameters for subcortical optogenetics.

    • Main Results:

    • Optogenetic inactivation led to clear and repeatable deficits in saccadic eye movements.
    • Demonstrated successful application of optogenetics in monkeys for behavioral studies.
    • Identified key parameters for effective experimental design.

    Conclusions:

    • Optogenetic inactivation of the superior colliculus effectively impairs saccadic eye movements in monkeys.
    • This study provides a framework for applying optogenetics in primate research.
    • Careful consideration of light application, viral spread, and inactivation extent is crucial for successful optogenetic studies in non-human primates.