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Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
Electrophysiological low-frequency coherence and cross-frequency coupling contribute to BOLD connectivity
Liang Wang1, Yuri B Saalmann, Mark A Pinsk
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. wanglbit@gmail.com
Neuron
|December 11, 2012
Summary
Low-frequency brain oscillations, not gamma activity, drive correlated blood oxygen-dependent (BOLD) signals between brain areas. This cross-frequency coupling may link local neural activity to large-scale brain network function.
Area of Science:
- Neuroscience
- Systems Neuroscience
- Neural Oscillations
Background:
- Brain networks are typically identified by correlating blood oxygen-dependent (BOLD) signals between regions.
- The neural underpinnings of these interareal BOLD correlations remain largely unknown.
- Gamma-band neural activity is thought to influence local BOLD signals, but its role in network correlations is unclear.
Purpose of the Study:
- To investigate the neural basis of interareal BOLD correlations within a visual network.
- To determine the contribution of different neural oscillation frequencies to BOLD signal correlations across brain areas.
Main Methods:
- Defined a visual network in monkeys using BOLD correlations across different states (fixation task, task-free, anesthesia).
- Simultaneously recorded local field potentials (LFPs) from four areas within this network during a task-free state.
- Analyzed the relationship between LFP oscillations and interareal BOLD correlations.
Main Results:
- Low-frequency oscillations (<20 Hz) in LFPs, rather than gamma-band activity (30-100 Hz), were the primary drivers of interareal BOLD correlations.
- Low-frequency oscillations modulated local gamma-band activity within individual brain areas.
- Cross-frequency coupling between low-frequency and gamma-band activity was observed.
Conclusions:
- Interareal BOLD correlations are predominantly driven by low-frequency neural oscillations.
- Low-frequency oscillations play a crucial role in coordinating activity across distributed brain networks.
- Cross-frequency coupling may serve as a mechanism linking local neural processing to large-scale network dynamics.
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