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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Bendamustine-induced "flagellate dermatitis".

Bassel H Mahmoud¹, Melody J Eide

¹Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.

Dermatology Online Journal

|December 11, 2012

Summary

Flagellate dermatitis, a rare skin reaction, is typically linked to bleomycin chemotherapy. This study details the first reported case of flagellate dermatitis occurring after bendamustine treatment in a patient with chronic lymphocytic leukemia.

Area of Science:

Dermatology
Oncology
Clinical Case Reports

Background:

Flagellate erythema, characterized by linear hyperpigmentation, was previously documented exclusively after bleomycin therapy.
This distinctive dermatological reaction pattern had not been associated with other chemotherapy agents.

Observation:

A rare case of chronic lymphocytic leukemia (CLL) is presented.
The patient developed a characteristic "flagellate dermatitis" following bendamustine administration.

Findings:

This report documents the first instance of flagellate dermatitis induced by bendamustine.
Bendamustine is identified as a potential causative agent for this rare chemotherapy-induced skin reaction.

Implications:

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The findings expand the known spectrum of chemotherapy-induced flagellate dermatitis.

Clinicians should consider bendamustine as a potential cause of flagellate dermatitis in patients undergoing treatment for hematological malignancies.