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Adrenal cortical function after long-term beclomethasone aerosol therapy in early childhood
1Department of Pediatrics, University of Calgary, Alberta, Canada.
Annals of Allergy
|April 1, 1990
Insights
Beclomethasone dipropionate aerosol (BDA) improved asthma symptoms in ten children. Adrenal function remained unaffected after up to 12 months of BDA treatment, as shown by tetracosactrin stimulation tests.
Area of Science:
- Pediatric Pulmonology
- Pediatric Endocrinology
- Clinical Pharmacology
Background:
- Asthma is a chronic respiratory condition affecting children worldwide.
- Inhaled corticosteroids, such as beclomethasone dipropionate aerosol (BDA), are a cornerstone of asthma management.
- Concerns exist regarding potential systemic effects of inhaled corticosteroids on adrenal function in pediatric patients.
Purpose of the Study:
- To evaluate the clinical efficacy of beclomethasone dipropionate aerosol (BDA) in asthmatic children.
- To assess the impact of long-term BDA treatment on adrenal function in pediatric asthma patients.
Main Methods:
- A cohort of ten children diagnosed with asthma participated in the study.
- Children received beclomethasone dipropionate aerosol (BDA) for a duration of up to 12 months.
- Adrenal function was assessed using tetracosactrin stimulation tests administered before and after the treatment period.
Main Results:
- All ten children experienced significant clinical improvement in their asthma symptoms during BDA treatment.
- Tetracosactrin stimulation tests revealed no demonstrable changes in adrenal function before and after BDA therapy.
- No adverse effects on adrenal function were observed in the studied pediatric population.
Conclusions:
- Beclomethasone dipropionate aerosol (BDA) is an effective treatment for improving asthma control in children.
- Long-term use of BDA, up to 12 months, does not appear to compromise adrenal function in pediatric asthma patients.
- BDA can be safely administered to children with asthma without significant endocrine side effects.
Abstract:
Ten asthmatic children were studied by tetracosactrin stimulation tests after receiving beclomethasone dipropionate aerosol (BDA) for periods of up to 12 months. Clinical improvement occurred in all children while receiving BDA. No change in adrenal function could be demonstrated by comparing the tetracosactrin stimulation tests before and after treatment with BDA.