Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial potential reflects T cell fitness and function during cancer immunotherapy.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Pharmacologic and Oncohistone Inhibition of SETD2 Converge on Genomic Instability.

Cancers·2026
Same author

Flipping the narrative on launching a rewarding career in academic medicine.

Nature cancer·2025
Same author

Targeted Metabolomic Methods for <sup>13</sup>C Stable Isotope Labeling with Uniformly Labeled Glucose and Glutamine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Journal of proteome research·2025
Same author

A SETD2-CDK1-lamin axis maintains nuclear morphology and genome stability.

Nature cell biology·2025
Same author

Vaccines in cancer treatment and prevention: the time is now.

The Journal of clinical investigation·2025
Same journal

Does size matter? A national analysis of patterns of adjuvant immunotherapy receipt and tumor size-dependent survival in pT3N0M0 clear cell renal cell carcinoma.

Urologic oncology·2026
Same journal

Ipsilateral sampling maintains clinically significant cancer detection and reduces overdiagnosis in PI-RADS 4-5 lesions.

Urologic oncology·2026
Same journal

Testis-sparing surgery for small testicular masses: Functional and oncological outcomes.

Urologic oncology·2026
Same journal

Subcapsular versus total orchiectomy in advanced prostate cancer: A systematic review and meta-analysis of clinical and patient-reported outcomes.

Urologic oncology·2026
Same journal

Featured SUO Fellow: Soum Lokeshwar, MD MBA.

Urologic oncology·2026
Same journal

Automating standardization of prostate cancer biopsy and histopathology reports with privacy-preserving local large language models.

Urologic oncology·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Kidney cancer.

W Marston Linehan1, W Kimryn Rathmell

  • 1Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. linehanm@mail.nih.gov

Urologic Oncology
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Kidney cancer encompasses diverse subtypes, understood as a metabolic disease influenced by genetic factors. Ongoing research into genetic mutations and novel therapies like immunotherapy offers hope for more effective treatments.

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Experiment Videos

Last Updated: May 16, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

  • Oncology
  • Genetics
  • Metabolic Diseases

Background:

  • Kidney cancer affects over 65,000 Americans annually, with nearly 13,000 deaths.
  • It is a heterogeneous disease comprising various subtypes with distinct characteristics.
  • Genetic factors are increasingly recognized as fundamental to kidney cancer development.

Purpose of the Study:

  • To explore the genetic underpinnings of kidney cancer.
  • To investigate the metabolic aspects of kidney cancer.
  • To review emerging therapeutic strategies for kidney cancer treatment.

Main Methods:

  • Analysis of 13 known kidney cancer-causing genes.
  • Review of recent discoveries in chromatin remodeling and histone modifying genes (e.g., PBRM1, SETD2).
  • Examination of novel immunotherapy agents (e.g., CTLA4 inhibitor ipilimumab) and targeted therapies.

Main Results:

  • Kidney cancer is characterized as a metabolic disease.
  • Specific genes like PBRM1 and SETD2 are crucial in its genetic basis.
  • New therapeutic targets include VEGF receptor signaling, mTOR pathways, and HIF2.

Conclusions:

  • Understanding kidney cancer as a metabolic and genetic disease is critical.
  • Advances in genetic research and targeted therapies show promise for improved patient outcomes.
  • Immunotherapy and novel agents represent promising directions for clinical trials and treatment development.