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Related Concept Videos

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Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Developing gelatin-starch blends for use as capsule materials.

Nuozi Zhang1, Hongsheng Liu, Long Yu

  • 1CPFRR, ERCPSP, School of Light Industry and Food Engineering South China University of Technology, Guangzhou 510640, China.

Carbohydrate Polymers
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Gelatin and modified corn starch blends create effective pharmaceutical capsule materials. Poly(ethylene glycol) improved blend properties, enabling successful hard capsule development.

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Area of Science:

  • Materials Science
  • Polymer Science
  • Pharmaceutical Technology

Background:

  • Gelatin is a common biomaterial for pharmaceutical capsules.
  • Developing alternative or improved capsule materials is crucial for drug delivery.
  • High amylose corn starch offers unique properties for material development.

Purpose of the Study:

  • To develop and characterize gelatin-starch blends as novel hard capsule materials.
  • To investigate the role of hydroxypropylation and poly(ethylene glycol) in blend performance.
  • To optimize the formulation and processing for pharmaceutical capsule production.

Main Methods:

  • Preparation of gelatin-starch blends with varying starch content.
  • Incorporation of poly(ethylene glycol) as a plasticizer and compatibilizer.
  • Characterization of solutions, films, and capsules using viscosity, tensile testing, contact angle, and SEM.
  • Optimization of temperature and incubation time for capsule formation.

Main Results:

  • Blends of gelatin with up to 50% hydroxypropylated high amylose corn starch were successfully developed.
  • Poly(ethylene glycol) enhanced blend transparency and toughness.
  • SEM analysis confirmed a continuous gelatin phase on film surfaces.
  • Optimized processing conditions allowed for the successful development of hard capsules.

Conclusions:

  • Hydroxypropylated high amylose corn starch is compatible with gelatin for capsule material development.
  • Poly(ethylene glycol) significantly improves the mechanical and optical properties of the blends.
  • The developed gelatin-starch blends are promising materials for pharmaceutical hard capsules.