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Pachydermodactyly: Three new cases in Taiwan
Chen-Kuan Chen1, Shyh-Dar Shyur2, Szu-Hung Chu2
1Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan; Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
Abstract:
Pachydermodactyly (PDD), Greek for thick-skin-finger, is an infrequently recognized benign disorder characterized by painless fusiform swelling of the soft tissues around the proximal interphalangeal joints of the hands. Histopathologic features include increased dermal accumulation of collagen fibers. Young males are predominantly affected. PDD is quite rare with approximately 90 cumulative cases reported worldwide. We report three new cases of PDD in Taiwan, including two female patients. Except for patient 1 having the habit of cracking the knuckles, and patient 2 having a history of patent ductus ateriosus post catheterization, the histories of all three patients were unremarkable. X-ray of bilateral hands revealed no abnormal finding except for soft tissue swelling around proximal interphalangeal joints. Laboratory examinations all showed negative results. No local or systemic treatment was given to these patients to treat PDD, with the exception of non-steroidal anti-inflammatory drugs prescribed to one patient for a short period. Skin care with local irritation avoidance was explained to all three patients. The long-term outcome of PDD was benign.
Insights
Pachydermodactyly (PDD) is a rare disorder causing finger swelling. This study presents three new cases, highlighting its benign nature and the need for awareness.
Area of Science:
- Dermatology
- Rare Diseases
Background:
- Pachydermodactyly (PDD) is a rare, benign condition causing painless swelling of finger soft tissues.
- Characterized by increased dermal collagen, it predominantly affects young males.
Observation:
- Three new cases of PDD in Taiwan are reported, including two females.
- Clinical presentation included painless fusiform swelling around proximal interphalangeal joints.
- Radiological and laboratory findings were largely unremarkable, showing only soft tissue swelling.
Findings:
- The cases align with PDD's known characteristics, despite variations in patient demographics.
- Histopathology consistent with increased dermal collagen accumulation.
- No specific treatment was required, with a benign long-term outcome observed.
Implications:
- Adds to the limited global case reports of Pachydermodactyly.
- Suggests PDD may occur in females more often than previously thought.
- Emphasizes the benign prognosis and conservative management approach for PDD.