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Can 2-oxoglutarate prevent changes in bone evoked by omeprazole?

Piotr Dobrowolski1, Ewa Tomaszewska, Radoslaw P Radzki

  • 1Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Lublin, Poland. piotr.dobrowolski@umcs.lublin.pl

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Proton-pump inhibitors like omeprazole negatively impact bone density and strength. Dietary 2-oxoglutarate did not prevent these adverse bone effects, though it did lower gastrin levels.

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Published on: June 8, 2014

Area of Science:

  • Biochemistry
  • Bone Biology
  • Pharmacology

Background:

  • Proton-pump inhibitors (PPIs) are widely used for gastroesophageal diseases.
  • Long-term PPI use is linked to an increased risk of bone fractures.
  • 2-oxoglutarate is a precursor to hydroxyproline, crucial for bone collagen.

Purpose of the Study:

  • To investigate the impact of omeprazole on bone health.
  • To determine if dietary 2-oxoglutarate supplementation can mitigate omeprazole's adverse bone effects.

Main Methods:

  • Eighteen male Sprague-Dawley rats were administered omeprazole in their diet and 2-oxoglutarate in drinking water.
  • Measurements included body and organ weights, serum hormone levels (cholecystokinin, gastrin), and bone histomorphometry.
  • Bone densitometry and peripheral quantitative computed tomography (pQCT) were performed on femurs and tibias.

Main Results:

  • Omeprazole significantly reduced femur and tibia weights, mechanical properties, bone density, bone mineral content, bone areas, cortical thickness, and periosteal circumference.
  • Omeprazole had minimal effects on bone morphology and cartilage.
  • 2-Oxoglutarate supplementation lowered gastrin concentrations.

Conclusions:

  • Omeprazole adversely affects bone mineralization and cancellous bone properties.
  • 2-Oxoglutaric acid did not significantly prevent the detrimental effects of omeprazole on bone.
  • 2-Oxoglutaric acid demonstrated an anti-hypergastrinemic effect.