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Related Experiment Video

Updated: May 16, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

C-reactive protein is elevated in schizophrenia.

Faith Dickerson¹, Cassie Stallings, Andrea Origoni

¹Stanley Research Program, Sheppard Pratt, Baltimore, MD 21204, United States. fdickerson@sheppadpratt.org

Schizophrenia Research

|December 11, 2012

Summary

This summary is machine-generated.

Individuals with schizophrenia show elevated high sensitivity C-reactive protein (CRP) levels, indicating increased inflammation. This suggests a potential risk for adverse health outcomes, warranting further investigation into interventions targeting CRP.

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Area of Science:

Neuroscience
Psychiatry
Immunology

Background:

Inflammatory markers are often elevated in schizophrenia.
High sensitivity C-reactive protein (CRP), a non-specific inflammatory marker, has been less studied in schizophrenia.

Purpose of the Study:

To compare high sensitivity CRP levels in individuals with schizophrenia, bipolar disorder, and healthy controls.
To determine the association between elevated CRP levels and schizophrenia or bipolar disorder.

Main Methods:

Measured high sensitivity CRP levels in 715 participants (295 schizophrenia, 192 bipolar disorder, 228 controls).
Used linear regression to compare CRP levels across groups, adjusting for covariates.
Employed logistic regression to calculate odds ratios for elevated CRP levels.

Main Results:

Schizophrenia patients exhibited significantly higher CRP levels than controls (p<.001), unlike bipolar disorder patients.
Schizophrenia was associated with increased odds of elevated CRP (OR 1.79 to 2.76, p<.012).
CRP levels correlated with Body Mass Index (BMI) and female gender.

Conclusions:

Elevated CRP in schizophrenia suggests potential health risks linked to inflammation.
Interventions aimed at reducing CRP and other inflammatory markers are recommended for individuals with schizophrenia.