[GDx-VCC NFI analysis in Lebanese glaucoma patients]

Area of Science:

• Ophthalmology
• Optometry
• Medical Diagnostics

Context:

• Glaucoma diagnosis relies on objective measurements of retinal nerve fiber layer (RNFL) thickness.
• The Nerve Fiber Index (NFI) derived from GDx VCC is a key parameter in assessing RNFL status.
• Understanding NFI parameter findings and progression is crucial for glaucoma management in diverse populations.

Purpose:

• To describe the Nerve Fiber Index (NFI) parameter findings and progression in Lebanese glaucoma patients or suspects.
• To evaluate the diagnostic utility of GDx VCC in a Lebanese cohort.
• To identify demographic factors influencing NFI scores.

Summary:

• A retrospective study analyzed GDx VCC examinations of 1063 Lebanese subjects (525 female, 538 male; mean age 56.8 years).
• Mean NFI score was 27.01 ± 14.23, with higher scores in males and older individuals. Glaucoma was detected or suspected in 383 subjects (36%).
• Among 136 patients with repeat testing over five years, 34.78% of initially normal subjects progressed to glaucoma suspect or confirmed glaucoma.

Impact:

• The study highlights that at least one in three subjects referred for GDx VCC testing had glaucoma detected or suspected.
• NFI scores demonstrate significant differences based on sex and age, necessitating consideration of these factors in interpretation.
• Findings suggest the potential for progression in individuals initially classified as normal, underscoring the need for longitudinal monitoring.