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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling

Luc Demange1, Fatma Nait Abdellah, Olivier Lozach

  • 1Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, Sorbonne Paris Cité, UFR Biomédicale des Saints Pères, 45 rue des Saints Pères, 75270 Paris cedex 06, France. luc.demange@parisdescartes.fr

Bioorganic & Medicinal Chemistry Letters
|December 11, 2012
PubMed

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