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Isolated pulmonary amyloidomas: report of 3 cases with histologic and imaging findings

Lauren Xu1, Aletta Frazier, Allen Burke

  • 1Department of Pathology and Radiology, University of Maryland Medical Center, Baltimore, MD, USA.

Pathology, Research and Practice
|December 11, 2012
PubMed

Insights

Pulmonary amyloidomas, rare lung masses, can mimic metastasis on imaging. These isolated lesions are not typically linked to lymphoproliferative disorders, aiding diagnosis.

Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Oncology

Background:

  • Amyloid tumors are uncommon causes of lung masses.
  • Distinguishing amyloidomas from malignant neoplasms is clinically important.

Observation:

  • Three patients presented with multiple lung masses, some suspicious for metastasis.
  • Pathologic evaluation confirmed amyloid tumor in all cases.
  • PET scans showed increased uptake, simulating neoplastic processes.

Findings:

  • Pulmonary amyloidomas were typically isolated lesions.
  • No association with lymphoproliferative disorders was found in short-term follow-up.
  • Macrophage giant cell reaction and plasma cells were noted histologically.

Implications:

  • Pulmonary amyloidomas should be considered in the differential diagnosis of lung masses.
  • PET imaging findings require careful interpretation to avoid misdiagnosis.
  • Understanding the benign nature of these lesions can prevent unnecessary aggressive treatment.

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