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Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial
Vivian A Fonseca1, Lawrence A Lavery, Tina K Thethi
1Tulane University Health Sciences Center, New Orleans, LA 70112, USA. vfonseca@tulane.edu
The American Journal of Medicine
|December 11, 2012
Summary
This study found that a combination of L-methylfolate, methylcobalamin, and pyridoxal-5'-phosphate (LMF-MC-PLP) effectively alleviates peripheral neuropathy symptoms in type 2 diabetes patients. While not improving nerve function tests, it significantly reduced symptom scores and improved quality of life.
Area of Science:
- Neurology
- Metabolic Disorders
- Nutritional Science
Background:
- Diabetic peripheral neuropathy is a common complication of type 2 diabetes.
- Sensory neuropathy significantly impacts patient quality of life.
- Nutritional deficiencies in B vitamins can exacerbate neuropathy.
Purpose of the Study:
- To evaluate the efficacy of a combination supplement (L-methylfolate, methylcobalamin, pyridoxal-5 extprime-phosphate) in improving sensory neuropathy in patients with type 2 diabetes.
- To assess the impact of this combination on nerve function (VPT), symptom scores (NTSS-6), quality of life (SF-36), and biochemical markers.
Main Methods:
- A multicenter, randomized, double-blind, placebo-controlled trial was conducted with 214 patients.
- Participants received either the active supplement (LMF-MC-PLP) or a placebo for 24 weeks.
- Primary endpoint was Vibration Perception Threshold (VPT); secondary endpoints included symptom scores and biochemical markers.
Main Results:
- No significant improvement in VPT was observed.
- Patients receiving LMF-MC-PLP reported significant symptomatic relief, with improved NTSS-6 scores at 16 and 24 weeks.
- Homocysteine levels decreased significantly with the supplement, and quality of life measures improved.
Conclusions:
- LMF-MC-PLP is a safe and effective short-term therapy for alleviating peripheral neuropathy symptoms.
- Further long-term studies are needed to assess effects on nerve function (VPT).
- Additional research on efficacy in cobalamin-deficient patients is warranted.
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