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Published on: March 27, 2018
Associations between preoperative anemia and outcomes after off-pump coronary artery bypass grafting
Sonoo Matsuda1, Toshihiro Fukui, Jun Shimizu
1Department of Anesthesiology, Sakakibara Heart Institute, Tokyo, Japan.
Insights
Preoperative anemia did not independently predict adverse outcomes in patients undergoing coronary artery bypass grafting (CABG). This study found no significant link between anemia before CABG and increased risks of death or complications.
Area of Science:
- Cardiology
- Anesthesiology
- Internal Medicine
Background:
- Preoperative anemia's impact on outcomes after coronary artery bypass grafting (CABG) remains unclear.
- This study investigated outcomes in patients undergoing off-pump CABG with or without preoperative anemia.
Purpose of the Study:
- To assess differences in perioperative outcomes between patients with and without preoperative anemia undergoing isolated off-pump CABG.
Main Methods:
- A cohort of 1,123 patients undergoing isolated off-pump CABG was analyzed.
- Outcomes were compared between 254 patients with preoperative anemia and 869 patients without.
Main Results:
- Patients with preoperative anemia were older, more likely female, and had more comorbidities (diabetes, heart failure).
- Univariate analysis showed higher rates of adverse events in anemic patients, but multivariate analysis revealed preoperative anemia was not an independent predictor of operative death or complications.
Conclusions:
- Preoperative anemia was not found to be an independent predictor of postoperative adverse events in patients undergoing isolated off-pump CABG.
Background:
It is still unclear whether patients with preoperative anemia have worse outcomes after coronary artery bypass grafting (CABG) than patients without preoperative anemia. The aim of this study was to assess differences in outcomes between patients with and without preoperative anemia who underwent off-pump CABG.
Methods:
A total of 1,123 patients who underwent isolated off-pump CABG between September 2004 and December 2010 were enrolled. Perioperative outcomes were compared between 254 patients with preoperative anemia (hemoglobin level: males, <12 g/dL; females, <11 g/dL) and 869 patients without preoperative anemia.
Results:
Patients with preoperative anemia were significantly older and more likely to be female than patients without preoperative anemia. Patients with preoperative anemia had higher rates of diabetes mellitus, acute coronary syndrome, and history of congestive heart failure, and had lower ejection fraction and estimated glomerular filtration rate. Patients with preoperative anemia had a higher operative death rate than patients without preoperative anemia, but this difference was not statistically significant (1.6% versus 0.3%; p = 0.0501). Univariate analysis showed that postoperative low cardiac output syndrome, hemodialysis requirement, and the composite adverse outcome were significantly higher in patients with preoperative anemia than in patients without preoperative anemia. However, multivariate analysis showed that preoperative anemia was not an independent predictor of operative death, low cardiac output, hemodialysis requirement, or the composite adverse outcome.
Conclusions:
In patients undergoing isolated off-pump CABG, preoperative anemia was not an independent predictor of postoperative adverse events.
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