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Related Experiment Video

Updated: May 16, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Peripheral neuropathy caused by severe hypothermia.

S Løseth1, A Bågenholm, T Torbergsen

  • 1Department of Neurology and Neurophysiology, University Hospital of North Norway, 9038 Tromsø, Norway. sissel.loseth@unn.no

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

Severe hypothermia caused axonal degeneration of peripheral nerves. Long-term follow-up showed significant recovery of nerve function, indicating potential for restitution even after multi-organ dysfunction.

Related Experiment Videos

Last Updated: May 16, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Area of Science:

  • Neurology
  • Toxicology
  • Internal Medicine

Background:

  • Accidental deep hypothermia can lead to severe physiological insults.
  • Peripheral nerve damage is a potential complication of critical illness.

Observation:

  • A 29-year-old female experienced accidental deep hypothermia (13.7°C).
  • Initial nerve conduction studies (NCS) and electromyography (EMG) revealed absent sensory and motor responses, indicating severe axonal sensorimotor polyneuropathy.
  • Large nerve fibers were more affected than small fibers.

Findings:

  • Nerve function showed improvement in amplitudes and conduction velocities over 5 years.
  • Persistent muscular atrophy of hand muscles was noted.
  • Small fiber function tests and intra-epidermal nerve fiber density were evaluated years after the event.

Implications:

  • Severe hypothermia can cause significant peripheral nerve injury.
  • Nerve function may show substantial recovery over extended periods, even after multi-organ dysfunction.
  • This case highlights the potential for good restitution in severe axonal degeneration.