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Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Carrier molecules for use in veterinary vaccines
Volker Gerdts1, George Mutwiri, James Richards
1Vaccine and Infectious Disease Organization - International Vaccine Centre, University of Saskatchewan, Saskatoon, SK, Canada.
Vaccine
|December 11, 2012
Summary
Animal and human immunization is a cornerstone of infectious disease control. Advances in antigen production necessitate carrier technologies, such as glycoconjugates and nanoparticles, to enhance vaccine efficacy in veterinary medicine.
Area of Science:
- Veterinary immunology and vaccine development.
- Biotechnology and biomaterials science.
Background:
- Immunization is a long-standing, cost-effective method for infectious disease control in animals and humans.
- Recent advances in antigen production (recombinant DNA, synthesis) require carrier molecules for optimal immune responses.
Purpose of the Study:
- To review selected carrier technologies for veterinary vaccine development.
- To highlight advancements in glycoconjugate, peptide, microparticle, nanoparticle, and virus-like particle vaccines.
Main Methods:
- Review of current literature on carrier technologies in veterinary vaccinology.
- Analysis of different carrier systems and their impact on immune response.
Main Results:
- Carrier molecules are crucial for enhancing immune responses to novel antigens.
- Diverse carrier technologies, including nanoparticles and virus-like particles, show promise for veterinary vaccines.
Conclusions:
- Development of advanced carrier technologies is essential for improving veterinary vaccine effectiveness.
- Future veterinary vaccines will likely leverage innovative delivery systems for better infectious disease control.
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