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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
The IL-17F sequence variant is associated with susceptibility to tuberculosis
1Department of Clinical Laboratory, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai, 200433, PR China.
Gene
|December 11, 2012
Summary
Genetic variations in the interleukin-17F gene are linked to increased susceptibility to tuberculosis. This finding offers potential insights for developing new tuberculosis diagnostics and treatments.
Area of Science:
- Immunogenetics
- Infectious Diseases
- Genomics
Background:
- The interleukin-17 (IL-17) gene is crucial for host defense against infections like Mycobacterium tuberculosis.
- Genetic factors influence an individual's susceptibility to infectious diseases.
- The association between genetic variations in IL-17 and tuberculosis risk remains largely unexplored.
Purpose of the Study:
- To investigate the potential association between genetic variations in the IL-17 gene and susceptibility to tuberculosis.
- To analyze single-nucleotide polymorphisms (SNPs) in IL-17A and IL-17F in relation to tuberculosis risk.
Main Methods:
- Genotyping of three SNPs (rs1889570 and rs763780 in IL-17F; rs2275913 in IL-17A) using the SNaPshot technique.
- Recruitment of 596 pulmonary tuberculosis (PTB) patients, 176 extra-pulmonary tuberculosis (EPTB) patients, and 622 controls from a Chinese Han population.
- Statistical analysis to compare allele and genotype frequencies between patient groups and controls.
Main Results:
- Increased frequencies of the rs1889570 G allele and rs763780 C allele were observed in PTB patients compared to controls.
- An increased frequency of the rs763780 C allele was found in EPTB patients relative to controls.
- The CT/TT genotype of rs763780 was associated with higher susceptibility to tuberculosis compared to the CC genotype.
Conclusions:
- Genetic variation in the IL-17F gene is associated with altered susceptibility to tuberculosis.
- These findings may contribute valuable information for the development of novel tuberculosis diagnostic or therapeutic strategies.
- No significant differences in IL-17 SNPs were found when comparing PTB and EPTB patient groups directly.
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