Related Experiment Video
Updated: May 16, 2026
06:33
3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
[Ocular toxoplasmosis: from pathophysiology to microbiological diagnosis]
A Sauer1, O Villard, T Bourcier
1Service d'ophtalmologie, hôpitaux universitaires de Strasbourg, nouvel hôpital civil, BP 426, 67091 Strasbourg, France. arnaud.sauer@chru-strasbourg.fr
Journal Francais D'Ophtalmologie
|December 11, 2012
Summary
Toxoplasmosis is a common infection affecting 30% of the global population. Ocular toxoplasmosis (OT) is the leading cause of posterior uveitis in immunocompetent individuals, with advanced diagnostic tools improving patient management.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Parasitology
Context:
- Toxoplasmosis is the most frequent cause of posterior uveitis in immunocompetent individuals.
- Approximately 30% of the global population is seropositive for Toxoplasma gondii.
- Ocular toxoplasmosis (OT) affects an estimated 2% of infected individuals, with significant prevalence in France.
Purpose:
- To highlight the diagnostic advancements in identifying ocular toxoplasmosis.
- To emphasize the importance of laboratory confirmation in managing OT patients.
- To discuss the management of both congenital and acquired toxoplasmosis.
Summary:
- Despite high seroprevalence of toxoplasmosis, ocular manifestations like posterior uveitis are less common.
- Recent advancements in microbiological tools enhance the diagnostic accuracy of toxoplasmosis.
- Laboratory confirmation is crucial for effective patient management, especially in atypical presentations of ocular toxoplasmosis.
Impact:
- Improved diagnostic capabilities lead to better patient outcomes for ocular toxoplasmosis.
- Understanding the prevalence and management of OT is vital for public health.
- Accurate diagnosis aids in differentiating OT from other causes of uveitis, guiding treatment decisions.
Related Concept Videos
01:22Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
01:30Toxidromes: Clinical Features
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...