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Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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T Cell Types and Functions

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Related Experiment Video

Updated: May 16, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Lymphocyte transformation and autoimmune disorders.

C Tarella¹, A Gueli, M Ruella

¹Haematology and Cell Therapy Division, Mauriziano Hospital, Turin, Italy. corrado.tarella@unito.it

Autoimmunity Reviews

|December 11, 2012

Summary

Autoimmune disorders significantly increase the risk of non-Hodgkin's lymphoma (NHL). Treatments targeting B-cells, like rituximab and stem cell transplants, show promise for both conditions.

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Published on: April 11, 2019

Area of Science:

Immunology
Oncology
Rheumatology

Background:

Autoimmune disorders (AD) share epidemiological and pathogenetic links with lymphoma.
Patients with AD exhibit a markedly increased risk of developing non-Hodgkin's lymphoma (NHL), particularly Sjögren's syndrome, rheumatoid arthritis, and systemic lupus erythematosus.

Purpose of the Study:

To review the epidemiological features linking AD and NHL.
To explore pathogenetic factors contributing to lymphoma development in AD.
To discuss recent therapeutic advances applicable to both conditions.

Main Methods:

Literature review of epidemiological data on NHL incidence in AD.
Analysis of pathogenetic mechanisms involving B-cell activation in AD and lymphoma.
Examination of therapeutic strategies, including rituximab and autologous hematopoietic stem cell transplant (ASCT).

Main Results:

The incidence of NHL is significantly elevated in patients with various AD, with relative risks ranging from 2-4 to 40-fold higher than in the general population.
Aberrant B-cell activation and proliferation are key factors in both AD pathogenesis and the development of malignant lymphoid clones.
Therapies targeting B-cells, such as rituximab, and intensified treatments like ASCT, are effective in managing both B-cell NHL and certain refractory AD.

Conclusions:

There is a strong association between autoimmune disorders and an increased risk of lymphoma.
Targeting deregulated B-cells offers a unified therapeutic strategy for both autoimmune diseases and lymphoproliferative disorders.
Rituximab and ASCT represent promising treatment avenues for patients with overlapping AD and NHL characteristics.