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Relationship between ischemic stroke location and autonomic cardiac function.

Chien-Fu Chen¹, Hsiu-Fen Lin, Ruey-Tay Lin

¹Department of Master's Program in Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan, ROC.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|December 11, 2012

Summary

This summary is machine-generated.

Acute ischemic stroke (IS) commonly causes autonomic cardiac dysfunction. Brainstem strokes significantly alter heart rate variability (HRV), indicating increased sympathetic and reduced parasympathetic activity.

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Area of Science:

Neurology
Cardiology
Autonomic Nervous System

Background:

Autonomic cardiac dysfunction is a frequent complication following acute ischemic stroke (IS).
Understanding the impact of stroke location on autonomic function is crucial for patient management.

Purpose of the Study:

To investigate the effects of acute ischemic stroke, specifically its location, on cardiac autonomic function.
To analyze heart rate variability (HRV) parameters in patients with different stroke locations.

Main Methods:

Recruited 75 acute IS patients and 81 controls for autonomic cardiac function assessment.
Measured heart rate variability (HRV) and associated parameters.
Compared HRV in IS subgroups (right hemispheric, left hemispheric, brainstem) with controls.

Main Results:

Significant differences in HRV parameters (LF, HF, normalized LF, normalized HF, LF/HF) were observed between IS subgroups and controls.
Brainstem (BS) infarctions showed significant differences in LF, HF, and LF/HF ranges compared to controls.
BS infarction correlated with greater sympathetic modulation and reduced vagal activity compared to RH or LH infarctions.

Conclusions:

Acute ischemic stroke significantly damages the cardiovascular autonomic system, evidenced by HRV abnormalities.
Brainstem strokes may lead to a pronounced imbalance in autonomic activity, with increased sympathetic and decreased parasympathetic influence.